This study was carried out to evaluate the toxicity and serum lipid profile of pet- ether leave, stem bark and root extract of jatropha curcas in male albino rats. Fourty-nine (49) adult wister rats weighing between 160-240mg/kg was purchased and 14 wister rats were used for acute toxicity study while the remaining 35 rats were randomly divided into 7 groups of 5 rats each. The normal control (group 1) received normal saline, while groups 2 to 7 administered with leave, stem bark and root extracts of jatropha curcas at low dosse (200 mg/kg body weight) and high doses (400 mg/kg body weight). The extracts were administered orally for seven consecutive days, while the animals were sacrificed on the 8th day; blood samples were collected, allowed to stand for fifteen minutes and then centrifuged to obtained the serum for lipid profile analysis. This result showed that the oral administration of the leave, stem bark and root extract of Jatropha Curcas possess hypolipidemic activity and may be useful in the management of cardiovascular disease. While acute toxicity (LD50) of the Leave, Stem Bark and Root Extract of Jatropha Curcas is greater than 5000mg/kg hence its declared practically non-toxic to the experimental animals.