Abstract: Ocular drug delivery to the scientists is a fascinating field because of challenges and exquisite barriers encountered in the ocular milieu. Till now, non-invasive approaches in ocular delivery are not yet successful with respect to intervention/treatment of long term ocular diseases. In spite of adverse effects with invasive techniques, they have been demonstrated promise in the treatment of sight threatening complications. The use of intravitreal injections or intraocular implants is gaining momentum with paramount progress in design, safety and efficacy from last two decades. Various intravitreal injections and ocular implants were developed with a wide array of therapeutic application potentials targeting drug localization for an extended period of time. Miniaturization of implants for their direct injection eliminating surgical process is currently being explored. In this review, various modalities comprising these invasive techniques targeting posterior ocular tissues namely retina and vitreous humor are summarized.