Glutamic oxaloacetic transaminase and lactate dehydrogenase are present in brain. The present study was undertaken to investigate whether there was any change in cerebrospinal fluid glutamic oxaloacetic transaminase and/or lactate dehydrogenase levels in Alzheimer's disease. In the present case control study cerebrospinal fluid glutamic oxaloacetic transaminase and lactate dehydrogenase levels were assayed in 162 Alzheimer's disease cases and 149 healthy controls. Glutamic oxaloacetic transaminase levels of cases were highly significantly increased with respect to the levels of controls. Lactate dehydrogenase levels of cases were not significantly increased with respect to the levels of controls. Data from the present study might help in understanding the biochemical basis of Alzheimer’s disease. It is stressed that these findings should be supplemented by further prospective research.