This study was done to estimate the serum uric acid, phosphate and calcium level pre and post dialysis. To do these 50 patients with chronic renal failure and 20 apparently healthy individuals as control group were involved. Uric acid, calcium and phosphate level was determined for all patients and the control group and the result was analyzed using spss package. The mean of uric acid pre dialysis is significantly raised compared with that of the control group (9.4± 2.3 versus 3.9±0.9) mg/dl. And the mean of uric acid level post dialysis decreased after dialysis compared with that of before dialysis (2.9± 1.3versus 9.4±2.3) mg/dl and P.value 0.00. The mean of calcium pre dialysis is significantly decreased compared with that of the control group (5.4± 0.85 versus 9.8±0.8) mg/dl. And the mean of calcium level post dialysis decreased after dialysis compared with that of before dialysis (4.4±1.07 versus 5.4± 0.85) mg/dl. The mean of phosphate pre dialysis is significantly raised compared with that of the control group (5.7± 2.04 versus 3.7±0.46) mg/dl. And the mean of phosphate level post dialysis decreased after dialysis compared with that of before dialysis (3.1± 1.3versus 5.7±2.04) mg/dl and P.value 0.00. In the test group, serum uric acid, phosphate and calcium were no correlated with the duration of the disease.