Background: The hemostatic alterations play an important role in malaria pathogenesis and in the progression of disease. In severe infection the accelerated coagulation cascade activity with accelerated fibrinogen turnover increase the bleeding tendency and may lead to DIC. Objectives: This study was aimed to determine the Alteration of coagulation parameters in Plasmodium Falciparum malaria Patients and its correlation with degree of parasitemia in Khartoum state. Sudan; 2019. Material and method: Analytical cross sectional study, 170 blood samples were enrolled in this study.85 samples of blood were collected from patients with falciparum malaria and 85 samples were collected from healthy individual as control, then PT and APTT will be measured by coagulometer. Result: The mean of PT was significantly high in case than in control (14.201second vs 13.668 second, (P value (< 0.01)).While there was no differences in the mean of APTT between case and control (33.075 vs 33.192 second ) P value (0.735). Conclusions: Our study concluded that the mean of PT was significantly higher in case than control, While there was no differences in the mean of APTT between case and control, and There was no differences between the PT and APTT of case and control according to gender. And there is no correlation between degree of parasitemia in PT, APTT and age.