This study was done to estimate the serum uric acid level pre and post dialysis. To do this 50 patients with chronic renal failure and 50 apparently health individual as control group were involved. Uric acid level was determined for all patients and control group and the result was analyzed using spss package. The mean of serum uric acid pre dialysis is significantly raised compare with that of the control group (9.4±2.2 versus 3.7±0.8). The mean of uric acid post dialysis is significantly decreased compared with that of before dialysis (9.4±2.2 versus 2.7±1.2) and P.value 0.00. The sex frequency for pt with CRF (43.3% female and 56.7% male). The correlation between duration of disease and Serum uric acid significant negative correlation and the (P.value =0.01 r = - 0.40).