Solanum Melongena is a highly nutritive medicinal plant which is cultivated in many countries including Nigeria where it is mainly grown in the northern part of the country.The plant is also applied in folklore remedies in the treatment of different ailments.The present study was carried out to investigate the testicular antioxidant and lipid effects of the fruit of Solanum Melongena on male wistar rats. The rats were divided into three (3) groups of six (6) rats each. Group one (1) served as control and received distilled water. Group two (2) and group three (3) were treated with 200mg/kg bw and 400mg/kg bw of the hydromethanol (20:80) extract of Solanum Melongena respectively. Extract was administered orally as single daily dose for a period of 30 days. The results obtained showed that the extract caused significant increase in the superoxide dismutase and catalase enzyme activities and also signicantly reduced malondialdehyde level. The serum concentrations of total cholesterol and low density lipoprotein cholesterol levels were significantly reduced but the serum concentrations of the high density lipoprotein cholesterol was increased. This study have shown that extract of Solanum Melongena inhibit lipid peroxidation and may reduce the risk of coronary artery disease in male wistar rats.