Introduction: Physical inactivity is a major contributor to the overall burden of cardiovascular disease such as storke, coronary artery diseases and other non-communicable diseases like type 2 diabetes, breast cancer, and colon cancer while Physical activity is a key and important factor that contributes to decrease the risk of cardiovascular disease. The aim of this study is to determine the prevalence and predictors of physical inactivity in a rural population in Nigeria. Methods: A cross sectional rural population study involving 572 subjects aged 15 years and above. Socio-demographic data were obtained by face-to-face interview. Weight, height, waist circumference, hip circumference measurements were taken along with blood pressure measurements. Blood samples were taken for fasting blood sugar and lipid profile. Results: Five Hundred and seventy two had their data analysed with male to female ratio of 1:2.6. The overall mean age was 39.08±17.5 years. The overall prevalence of physical inactivity in this study was 3 % to 7.3% during commuting or working respectively with men being more active than females. The elderly age group of 70 years and above were more sedentary than all other age groups. Pearson correlation and Spearman’ rho correlation analyses showed that smoking and BMI correlated with obesity. Linear regression analysis showed that smoking and BMI predicted presence of physical inactivity. Conclusion: Physical inactivity prevalence in this study is low with smoking and BMI being important predictors.