Abstract: Chronic smoking adversely influences the prognosis of nephropathies. The objective of this study was to the relationship between renal damage and chronic smoking through parameters can bring a clear vision about kidney status.This study was a case control study, was conducted in Khartoum state,Microalbuminuria is defined as excretion of 30–300 mg of albumin per 24 hours (or 20–200 mcg/min or 30–300 mcg/mg creatinine) on 2 of 3 urine collections. Microalbuminuria is caused by glomerular capillary injury and so may be a marker for diffuse endothelial dysfunction. According to Steno hypothesis, albuminuria might reflect a general vascular dysfunction and leakage of albumin and other plasma macromolecules such as low density lipoproteins into the vessel wall that may lead to inflammatory responses and in turn start the atherosclerotic process. Apparent healthy subjects were randomly participate in this study, A fifty (50) subjects chronic smoker subjects were involved in this study and other ninety four (94) ones were considered as control group, statistical analysis for chemical results of creatinine, microalbuminuria (MIA) and calculated ACR (albumin/creatinine ratio) revealed significant different in creatinine in smokers group when compared to non-smokers group, and strongest relationship between creatinine and duration of smoking, and between MIA and ACR with number of smoked of packs per day.