COVID.19 Pandemic is a real disaster facing the globe, and up to date its uncontrollable , due to absence of data about the real mechanism upon which this virus overcome immune system and induce lethal symptoms certainly among aged and those with low-level of immunity. MNAD hypothesis based protocol aimed to measure validity of combination Minocycline as antibiotic, N. acetyl cysteine as antioxidant, aspirin as anticoagulant and vitamin D as immune regulator to treat COVID.19 infection. This protocol opened and implemented by any institutions or health authority after permission of the corresponding author of it.