The achievement in the science national examination of SMPN 1 Kertak Hanyar was low. The laboratory has not been optimally used for supporting learning activities. The main books used were not so interesting that they influenced the teaching and learning process. Development research was needed to get a good quality of science learning module based on laboratory activity. This research was aimed to (1) evaluate module validity; (2) evaluate module practicality, and (3) evaluate module effectiveness. The development research used Tessmer’s formative evaluation design. The research subjects were grade IX students of SMPN 1 Kertak Hanyar who were selected by convenience sampling of the probability method. Data obtained through research were those of the students’ learning achievements including cognitive learning achievement, science process skills, critical thinking skills, and critical thinking abilities. The results of the research indicated that the module based on laboratory activity can be used in learning activities because it has the criteria: (1) valid, mean 3,83 based on six criteria, such as design, language, and organization, material, format, presentation, supporting innovation and improving the quality of teaching and learning activities; (2) practical, based on five criteria, such as content attractiveness, appearance attractiveness, ease of material description, ease of illustration or image, and ease of practicum steps, and (3) effective, based on four criteria, such as cognitive learning achievement, science process skills, critical thinking skills, and critical thinking abilities.