Background: The phenomenon of cytokine storm is responsible for the pathogenesis and severity of COVID-19, which lacks specific drug treatment and vaccine for prevention. Thus, this report suggested that albendazole anthelminthic drug administration might reduce cytokine storm in COVID-19 patients. Method: This longitudinal study assessed serum levels of cytokines (IFN–γ, IL-4 and IL-8) usig ELISA in apparently healthy Nigerian adults before and 4 weeks after oral 400mg single dose of albendazole anthelminthic drug administration. Data presented as Median (Interquartile range) were analysed using Wilcoxon Signed Ranks Test, with levels of significance set at α0.05. Results: Serum median levels of IFN–γ and IL-8 were significantly reduced at 4weeks post- albendazole administration (p < 0.05) while IL-4 was insignificantly reduced at 4weeks post- albendazole administration (p > 0.05) compared with median levels before albendazole administration. Conclusion: Since albendazole administration reduces serum IFN–γ and IL-8 which are involved in COVID-19 cytokine storm, it is suggested that albendazole has potential for the management of cytokine storm in COVID-19 patients. This however needs further clarification.