Neonatal sepsis (NNS) is invasive infection, mostly bacterial, occurring during the neonatal period. NNS manifests with ill-defined symptoms, therefore, requires high index of suspicion for early diagnosis. Neonatal sepsis is becoming less frequent due to improved obstetrical management and evidence-based use of intrapartum antimicrobial therapy. However, early-onset sepsis remains one of the most common causes of neonatal morbidity and mortality in the preterm population.