Stroke is defined as the loss of function of brain and it occurs when the supply of blood to the brain is either interrupted or reduced. When this happens, the brain does not get enough oxygen or nutrients which cause brain cells to die. Stroke induced brain injury results from the interaction of various complex pathophysiological modalities such as excessive accumulation of excitatory amino acids, ROS, calcium overload, mitochondrial damage, neuronal cell death etc. For the last three decades animal models of cerebral ischemia were developed with the aim of identifying mechanisms that cause tissue damage and to provide the basis for the development of new therapies for stroke at a preclinical level. The three main classes of in-vivo animal models are global ischemia, focal ischemia, and micro embolism/thrombosis model. In vivo experimental models to induce stroke are either global or focal models, each of them have their own advantages and disadvantages. In order to overcome the disadvantages, in the present study, we had combined both global and focal models i.e. Common carotid artery occlusion along with 25% Fecl3 induced thrombosis. The model bilateral Common Carotid Artery Occlusion combined with Ferric chloride Induced Thrombosis and Reperfusion (BCCAO+FIT+RE) was more successful than the other groups such as Unilateral Common Carotid Artery Occlusion (UCCAO+RE), Bilateral Common Carotid Artery Occlusion (BCCAO+RE) and Ferric chloride Induced Thrombosis (FIT) in inducing stroke.