Objectives: To investigate the Quality of Life (QOL) of Family care givers and characteristics of QOL associated with caregivers who are involved in the care of individuals with Cerebro Vascular accidents patients. Research Methodology: Descriptive cross-sectional study was conducted with a sample size of 50 caregivers of stroke patients taken from four different hospitals of Lahore. Non-probability convenient sampling technique was used. Data was collected by questionnaire of assessment of Quality of Life of family caregivers translated into Urdu version. Findings and Discussion: A Significant high ratio of female caregivers was found, out of 50 caregivers only 20 (40.0%) were male. According to data, the average score of Social relationship domain score 63.7 ± 18.4 was followed by Psychological 58.8 ± 15.1 and Physical health domain score57.4 ± 17.6 as compared to the Environment domain score. The environment domain score 53.5 ± 15.4 was lowest as compared to all four domains’ score. Conclusion: Findings of this study suggested that environmental domain is a leading factor for poor Quality of Life. It is needed to improve the environment and surroundings of patient care premises to improve quality of life of caregivers in hospital. Hospital policy, resources, set up and certain interventions were required to improve the caregivers’ quality of life.