Background: Fever is a common medical problem among children that always prompts mothers to seek medical care. Aim: To evaluate the effect of educational protocol for improving mothers’ practices on the types of fever in Zagazig City. Design: A quasi-experimental research design [pretest -posttest] was used. Setting: At Chiba MCH center, in Zagzig City. Sample: A purposive sample consisted of 96 mothers were chosen according to inclusion criteria. Tools: Three tools were used; Interview Questionnaire sheet, the mothers’ knowledge of fever, and mothers’ practice in management of their febrile child. Results: Showed that about 33.33% of the mothers aged between 35 and 40 years, about 72.91% of them were married, nearly 64.58% of them had work. Also, about 63.54% of them reported that they were from rural areas. Also, there were statistically significant totally improvements in the mothers' knowledge and practices regarding the focused problem at (p<0.001) in the post-protocol phase. There were highly statistically significant positive correlation between mothers’ total knowledge and practices pre and post-protocol (r =0.802, and 0.617) respectively. Conclusion: The applying of educational protocol among mothers was effective in enhancing their knowledge, and practices regarding types of fever and their management. Recommendation: Further educational protocols in the pediatric clinics or via mass media for mothers about fever should be implemented.