Every year, over 250,000 patients have cardiac surgery and the incidence of cardiac arrest. When treated quickly, 17% to 79% of patients who experience cardiac arrest after cardiac surgery survive to discharge. Many of health care providers found this was disorganised and they would have performed better if they had well defined roles. Objectives: The aim of the study is to assess the level of knowledge among novice nurses regarding cardiac advance life support surgery (CALS) in cardiac surgery intensive care unit (CICU) and Cardio pulmonary department (D1 department) of Aga khan university hospital. Material and Methods: The descriptive cross-sectional study done. The 15 nurses were selected as sample to assess knowledge. Results: Novice nurses were not aware about (CALS). Moreover we developed module for nurses for future education and awareness about CALS the later study will help to assess the efficacy of CALS module. Conclusion: The study helps to make module of CALS for nurses taking care of patient underwent open heart surgery.