The Aspergillosis of the Paranasal sinuses is a well-recognized form of fungal infection, the involvement of the pituitary gland by aspergillosis is extremely rare. In which the main pathogen of the fungal seller is aspergillus classes. The pituitary infectious fungi consisted of different groups and dimorphic fungi. The leading pathogen of fungal seller abscess is the type of aspergillus. The possible route of infection through sphenoid sinus with a thin seller roof. A pituitary tumor differentiates through its size. Pituitary tumors undesirably are known to grow in the sphenoid bone, cavernous sinus, mid-nasal ductus, and left cerebral hemisphere. In our case presentation patient presented with pituitary macroadenoma, which diagnosed through magnetic resonance imaging. Presented with nasal mass, and acromegaly features headache. Right eye vision loss. Through endoscopy, biopsy report shows the nasal fungal infection. Surgical treatment, the trans-sphenoidal procedure will be planned as recommended in literature reviews.