The study was aimed at evaluating effectiveness of coping strategies intervention on caregivers’ burden among caregivers of dependent elderly in selected hospital, Kozhikode. The objectives of the study was to assess the caregivers’ burden among the caregivers of dependent elderly before administering the coping strategies intervention, to evaluate the effectiveness of coping strategies intervention on caregivers’ burden among caregivers of dependent elderly, to find out the association between caregivers’ burden and selected demographic variable. The research approach used for the study is quantitative approach, the research design used for the study is one group pre-test post-test design, and sampling technique used for the study is convenience sampling technique. 30 caregivers of dependent elderly were taken as the subjects. The study was conducted in selected general wards in MIMS hospital, Kozhikode. Demographic data and caregivers’ burden scale were the tools used for conducting the research. Data analysis was done by descriptive and inferential statistics. The present study showed that 60% of subjects had mild to moderate burden and about 40% had little or no burden before administering coping strategies intervention. In posttest all the subjects had only little or no burden. The mean caregivers’ burden in the intervention group decreased. Calculated paired t value (13.03) was greater than the table value (2.05) at df 29. Finally study showed that coping strategies interventions are effective in reducing the care givers’ burden. And also there is a significant association between religion and caregivers’ burden.