Communication climate influences quality of work environment as it contributes to the effectiveness and success of an organization. Organizations with positive communication climate have good employee relationships that in turn improve staff empowerment and career growth. Aim: The current study aims to determine the impact of communication climate on nurses’ organizational career growth and empowerment. Research design: Quasi-experimental research design has been carried out. Setting: The study conducted in (General medical and surgical departments) at Qena and Sohag University Hospitals. Sample: All available nurses working in the designated sites 98. Tools: three tools were used, communication climate questionnaire, organizational career growth scale, and conditions of work effectiveness questionnaire II. Results: The present study findings that there were highly statistical significance differences of communication climate, organizational career growth, and structural empowerment between the two hospitals X2 = 16.843, 18.18 and 30.247 respectively & P<0.01. Regarding means and standard deviations it was 54.20±9.35 & 41.39±13.47 for communication climate, 47.02±8.60 & 37.69±10.05 for organizational career growth, and 55.20±9.39 & 41.04±11.60 for structural empowerment at Qena and Sohag University Hospitals respectively. Conclusion: The improvement in the communication climate results in higher levels of organizational career growth and structural empowerment. Recommendations: Management should develop and maintain communication climate that enables free expression of ideas and exchange of opinions among staff. Managers should encourage nurses’ empowerment for effective organizational performance. Nurses’ organizational career growth and continuing education are important for improving staff performance and skills.