Background: Adolescent and young adults with cancer are a unique population, but not much is known about their endof-life sexual preferences and trajectories. Limited information is available on the sexual need of terminally adolescent cancer patients. Objective: Follow-up of 3 young unmarried female terminal cancer patients; all of them had a wish of losing their virginity before dying. Results: Two of the patients were in their late teens and one 22, all had advanced disease. One patient received only alternative herbal treatment for her osteogenic sarcoma; the other patient received conventional plus alternative homeopathy therapy after relapse of her brain tumour (Glioblastoma multiforme) and the last patient had only conventional treatment for her chronic lymphoid leukaemia. Two patients could fulfil their wish of losing virginity, in one it was possible after her marriage. One patient committed suicide after she became pregnant, and the other two died because of the disease. Conclusion: Adolescents and young adults with life-limiting illnesses have a tendency to indulge in some crazy activities before dying. Sex can be one such activity they may want to attempt. It is therefore important to counsel adolescent cancer patients about high-risk sexual behaviours. Special space could be created after obtaining necessary permission from the concerned authorities where open minded volunteer (boy/girl) can spend some intimate time with the terminal cancer patients under the supervision of health care providers.