This study was conducted to assess the nurses‟ knowledge & practices regarding crash cart. “Emergency nurses require a strong knowledge base in every area of nursing during their practices, from pathophysiology to psychology, pharmacology, policies and procedures, and everything in between” [1]. Drug administration is a fundamental part of every day in nursing profession. No medication is completely safe and protected in this manner. Therefore, nurses need to have an intensive and broad knowledge of the medications and its method of organization in the compelling treatment of patients whose life lies in her grasp [2]. A quantitative descriptive cross-sectional study design was performed to assess the nurses‟ knowledge and practices regarding crash cart. Data was collected through simple random sampling technique. I select public health tertiary hospital to collect relevant information and data of my study from nurses working in it. There are 265 nurses in hospital I selected 160 of them by using sampling technique with 5% estimation error. The data was analyzed through SPSS 16 version. The results were shown in tables and graphs. The main results found are,(n= 94) 58.8% participant are respondent medication checked periodically and exchanged based date on expiry, and (n=66) 41.3% participant are respondent medication not checked periodically and exchanged based date expiry. In conclusion, I would say the areas of improvement entitle to the nursing staff with increased knowledge, practice and responsibility, accountability for improving management for crash cart within the public health tertiary hospital Lahore.