Chronic renal failure (CRF) is a life-threatening disease in which a patient needs a long-term treatment such as hemodialysis, kidney replacement to save his life. Aim: this study was aimed to identify the relation between stressors, self efficacy and level of hope for patients with CRF, undergoing hemodialysis. Design: a descriptive correlation research design was utilized in this study. Setting: The study was conducted at King Fahd unit for hemodialysis at, ELManial hospital, Cairo University. Subjects: a purposive sample of 160 patients with CRF undergoing hemodialysis. Tool of data collection: Socio-demographic datasheet,hemodialysis stressor scale(HSS) ,self efficacy scale &Herth hope scale. Results: Showed that more than two thirds of the studied subjects undergoing hemodialysis for more than 24 months less than two third of them were suffering from moderate degree of stress, more than fifty percent of the studied subjects had high levels of hope, while less than fifty percent of them had a moderate level of hope. Conclusion: The highest percentage of the studied subjects were suffering from moderate degree of psychosocial stressors, such as depression, sadness, changed in family responsibility and dependence on others, statistically significant negative correlation was found between stress and self-efficacy. Moreover, a negative correlation was found between stress and level of hope while, there is no, statistically significant correlation between self-efficacy and level of hope. Recommendation: Supportive and therapeutic intervention program should be provided for both patients with chronic renal failure and their families to alleviate their stress ,increase sense of hope and improve their quality of life.