Background: Health care employees need stress reduction and burnout prevention more than ever thought. Aim of study: to evaluate the effect of an intervention program on job stressors and burnout among preretirement employees in Health Insurance Hospital at 10th of Ramadan city. Subjects and Methods: The study was carried out in the Health Insurance Hospital at 10th of Ramadan city using a quasi-experimental design with pre-post assessment on a convenience sample of 100 preretirement employees. A self-administered questionnaire was used in data collection with scales for assessment of job stress and strain, and burnout. The fieldwork was achieved from July to December 2017. Results: Participants were mostly females (67%), at 50-year age (45%). The highest job stressor was the clinic-related one (73%). In total, 63% had high stressors at pre-intervention phase, compared to 29% and 36% at post-and follow-up phases respectively (p<0.001). Also, 36% had high strains before the intervention, which significantly dropped to 20% after the intervention, and to 13% at follow-up. Overall, 29% had high burnout before the intervention, which significantly declined to 9% at postintervention phase, but increased again to 36% at follow-up phase. In multivariate analysis, the intervention was the main significant independent negative predictor of employees’ stress and strain scores, while the stress score was a significant positive predictor of the total burnout score. Conclusion and Recommendations: The intervention program is effective in reducing the levels of stress, strain, and burnout. It is recommended to implement it in the study settings and in similar ones, with improvements of its burnout aspects.