Population growth, aging, and sedentary lifestyles, particularly in developing countries, will create a crisis for population health that requires a multisystem response with musculoskeletal health services as a critical component. The prevalence and impact of musculoskeletal conditions increase with aging. Aim of this study assesses lifestyle elderly women Suffering from knee osteoarthritis pain. A descriptive research design used in this study. Was conducted at out patient orthopedic and rheumatology clinics at Nasr City Hospital and the Nile Hospital, affiliated to the National Health Insurance Organization Cairo Egypt. A purposive sample of 120 elderly women with OA. Tools the investigator will use four tools for collection of the data, namely an interview questionnaire, Lawton scale for the Activities of Daily Life Arthropometne measurement, Measure Body mass index, and a pain. Revealed 85% of study subjects from urban areas, suffered from OA since many years, and 68% Unsatisfactory knowledge and Adequate practices 71.7% and 80% was obese, and 73% suffered from Moderate pain. The results of the study show the lifestyle practices older women are higher than women's knowledge and higher in cases of moderate obesity and moderate pain in most elderly women. Health education about lifestyle modification, practice exercise should be provided to all female with OA attended to orthopedic and rheumatology clinic.