Occupational hazards are termed as workplace undesirable activities that can cause an injury or ill health among the health care workers at their work place Aluko et al., 2016. In discharging their duties, nurses encounter a variety of occupational health problems which may be categorized into biological, chemical, mechanical, and psychosocial hazards Manyele, Ngonyani, & Eliakimu, 2008. The main aim of this study is to determine the knowledge and attitude of clinical practicing nurses regarding occupational hazards at the selected hospital. A Descriptive Cross sectional design was used to assess the awareness of nurses regarding the occupational hazards and its management. A quantitative non experimental approach was applied. A sample n=200 registered nurses was drawn from the list of all registered nurses at Mayo Hospital Lahore through convenient sampling. A self-administered questionnaire was adopted from a previous study. The adopted questionnaire meets the basic purpose and objectives of this current study. All the questions were written and formulated simply. The data collection tool consists of closed ended questions with Yes and No for Knowledge and Likert scale of agreements and disagreements for Attitude. After the data categorized and entered in to the computer, it will be analyzed with the help of SPSS software (version 21). Religion and Knowledge of occupational hazards is having significant association (p value= .001). Furthermore Marital status of the participants is significantly associated with the knowledge and attitude towards the occupational hazards among nurses. The chi squire tests are having significant association (p value= .000) less than .05. Moreover Knowledge and attitude of occupational hazards showed a significant relationship with having Pearson chi square values (p values .000). In conclusion, the Knowledge ad attitude of occupational hazards was found to be associated with different factors such as Education, Marital status and religion etc.