From the above medical crises it is strictly order to for the first fifteen minutes of the blood transfusion the nurse should stay with the patient to closely monitored c for any signs of adverse effects (Allan & and Bates 2004). The main purpose of the study is to assess the practices of blood transfusion among clinical nurses at a public tertiary care hospital Lahore. In this study across sectional descriptive design was used. The study was conducted at Mayo hospital at all the critical and other inpatients areas. A questionnaire adapted from thesis of Ebenezer tetteh (2015) “Knowledge and practice of blood transfusion among nurses in Ghana: experiences from the cape coast teaching hospital, this questionnaire was used to collect data from the respondent. Questionnaire consists of 2 parts first focusing on demo-graphic data of participant and second is lekert scale questionnaire which is based on practice data. Analysis of variables was done on SPSS 21. The overall practice results shown in the above table and graph reveals that there were no participants in the poor practice category. 63.56% of the participants had moderate practices having score of practice between 45 and 80 on a maximum score of 108. 36.44% of the study participants had good practices and scored above 80 score on a maximum of 108 practice total score. Majority of the participants was having moderate practices of Blood transfusion but there were no as such poor practices.