Liver transplant is the corner for patients with end stage liver diseases. Posttransplant patients face many challenges including poor general health, physical inactivity and emotional problem. This article reviews studies that explored the impact of physical activity on health related quality of life (HRQOL) for post liver transplant patients. To collect evidence to supporting the relationship between physical activity and HRQOL for post liver transplant patients, a search of the PubMed, CINAHL, Psych Info, EbscoHost, Medline, and ProQuest Dissertations and Theses databases was conducted using key phrases, including chronic liver disease, liver transplant, post liver transplant, liver transplant and physical activity, liver transplant and health-related quality of life. The main search parameters were studies written in English and those conducted between 2005 and 2014. The initial search resulted in 957 records. There were 246 duplicate records. These records were removed. Records were excluded if patients were pediatric, secondtime transplant recipients or receiving more than one organ transplant or if they had active infections. First records were excluded by screening the record titles; 453 records were excluded using this method. Next, records were excluded by screening the abstracts; 214 records were excluded using this method. Finally, records were excluded by screening the entire record text; an additional 37 records were excluded using this method.