This study aimed to evaluate the effect of an educational program on nursing performance regarding advanced cardiopulmonary resuscitation. A QuasiExperimental Study. The study conducted at the emergency department at Ain Shams University hospital and children hospital affiliated to Ain Shams University hospitals. A convenience sample included all available nurses (100) , at the previously mentioned settings over a 6 months’ period. Pre-designed sheet; it was concerned with their knowledge regarding advanced cardiopulmonary resuscitation.