Hepatitis C Virus (HCV) educational interventions are one option for helping these patients adhere to treatment recommendations while improving their quality of life. The aim of this study is to determine the effect of health-related quality of life educational interventions on Chronic Hepatitis C Patients'. A quasi-experimental study design. This study was conducted at the liver outpatient clinic of Fayoum Medical University Hospital. A purposive sample of hundred fifty patients was included. Tools: 1) Patients' needs assessment questionnaire. 2) Health-Related Quality of life of Chronic liver disease questionnaire (CLDQ).