Depression is a major public health problem. It is the most common mood disorder in later life associated with serious consequences, including; disability, functional decline, diminished quality of life, increased mortality and increased service utilization. This study aims to assess the impact of a health promotion program on quality of life, depressive symptoms and feeling of loneliness among institutionalized elderly in Egypt. Design: a quasi-experimental one group pre-posttest research design was utilized. Sample: A convenience sample of (60) institutionalized elderly was selected. Setting: the study was conducted at Dar El- Hanna nursing home. Tools of the study: A structured questionnaire included personal data, health assessment data and institutionalization data. Quality of life index, UCLA loneliness scale as well as geriatric depression scale were utilized. Results: revealed that, more than half of elderly were institutionalized due to absence of caregivers. A statistically significant relationship was found between duration of residence, and quality of life. There were statistically significant relationships between mean scores in pre and posttest for quality of life index in relation to satisfaction aspect at p=0.001*, overall quality of life scale (at p=0.008*), UCLA loneliness scale (at p=0.001*) and geriatric depression scale (at p-0.003*). Conclusion: the study concluded that application of health promotion program for institutionalized elderly had a positive impact on reducing depressive symptoms and level of loneliness and has improved quality of life among institutionalized elderly. Recommendation, Further psychosocial intervention and qualitative studies are needed to overcome loneliness and depression and to improve quality of life among institutionalized elderly. A specialized gerontological mental health nurses should be there for elderly in nursing homes in Egypt. Elderly should also be involved in regular physical, mental and recreational activities to enhance their physical, social and psychological health and wellbeing.