In 21st century while we still can’t perform miracles in healing to maintain health, one Elixir is coming into the limelight is Placenta Extract which will aid magic in the era of wound healing. In other words, the Placenta act as various internal organs for the embryo, that’s why it has a various medicinal effects, studies have shown magical effects of wound healing by use placentrex. A troublesome and usually unavoidable consequence of Head and Neck chemo radiation is oral mucositis which decreases patients’ compliance and negatively influences the outcome of therapy by increasing overall treatment time. Currently, no single effective recommended treatment exists for this problem and a variety of supportive care measures have been practiced with limited benefits. While many study evaluated the therapeutic benefit of Placentrex in the management of oral mucositis seen in oral cancer patients undergoing treatment with concurrent chemoradiation. Even local injection of placentrex proved to be safe, cheap and effective in oral submucous fibrosis without any significant side effects and contra indication. The effect is long lasting. So can be given in early stages of OSMF with significant results. This review focuses on the use and benefits of placentrex in dentistry.