Vagina is a part of the female genital tract leading from external genitals to the cervix of the uterus. It is a muscular and an elastic organ. There are various malformations that can occur in the female genital organ, one among them being Mullerian Agenesis. Mullerian agenesis/ MRKH syndrome is a congenital anomaly in females due to the developmental failure of vagina from the mullerian duct. This results in aplasia of the uterus/ vagina or presence of rudimentary uterus and upper part of the vagina.1 It is the most common cause of primary amenorrhea. Women with vaginal agenesis usually suffer from mental depression and they are deprived of a normal social life. It is mandatory to educate and motivate the patients and their family about the various treatment options available and carry out the treatment which is best suited according to the patient’s needs. The most common treatment modalities include non-surgical methods, surgical methods or combination of both. Surgical creation of neovagina along with the use of a neovaginal prosthesis can go a long way in improving the quality of life of the patient. This article presents a case report of a young woman with MRKH syndrome who was referred to the Department of Prosthodontics for fabrication of a neovaginal prosthesis which was to be used after surgery to maintain a patent passage. The neovaginal prosthesis was fabricated by a Maxillofacial Prosthodontist using autopolymerizing acrylic resin.