Background: Multiple myeloma is the majorly occurring plasma cell dyscrasia. It involves the plasma cells, bone marrow and kidneys. There is monoclonal proliferation of plasma cells which secrete light chain immunoglobulins IgG type. These immunoglobulins tend to precipitate in the form of para proteins. It has a very complex pathogenesis which makes difficult to predict the prognosis of the disease. Therefore, majority of cases go into phase of relapse or progression and may sometimes present with bone lesions which were not present in the primary disease. Case Report: A 52 year male patient presented to the out patient department of our institute. He was a known case of multiple myeloma and was in the remission phase. He complained of pain in 46 and 47 region which he had undergone extraction 3 months back. On evaluation, the lesions were found to be bone lesions present in multiple myeloma. Therefore, a diagnosis of relapse case of multiple myeloma was given. Conclusion: Multiple myeloma is a disease of variable prognosis and needs to have thorough follow up protocols and an interdepartmental approach, in order to have an early diagnosis and treatment.