Cleft lip and palate are the utmost typical facial deformity. It may occupy lip only, lip and palate and palate only. The primary deduction of clefting in infants may be each environmental or genetic aspects (such as familial factors and chromosomes). The amount of professionals involves in management of clefting and decides the highest treatment plan depending on the site of deficiency and period of the infant. Aim: The principle of the current paper is to present the etiology of cleft lip and cleft palate mutually the genetic and the environmental aspects. It is optional that the genetic basis for dissimilar kinds of familiar or unusual congenital malformations may marvelously be homogeneous, even as, the ecological basis is heterogeneous. Etiology: The etiology of CLP looks multifaceted, with genetics playing a vital function. Numerous genes create syndromic CLP have been exposed. Three of them, T-box transcription factor-22, poliovirus receptor-like-1, and interferon regulatory factor-6 are accountable for generate X-linked cleft palate, cleft lip/palate-ectodermal dysplasia syndrome, and Vander Woude and popliteal pterygium syndromes, correspondingly; they are also occupied in nonsyndromic CLP. Conclusion: To terminate, while the etiology of nonsyndromic CLP is still mostly unidentified, mutations in applicant genes have been known in a tiny amount of cases. Formative the qualified menace of CLP on the basis of hereditary conditions and environmental manipulate (together with smoking, alcohol use, and dietary factors) will be practical for genetic analysis and the expansion of future protective procedures.