Aim of the study: The purpose of the study was to assess the preferences of intra-canal medicaments of Endodontists and their method of delivery into the root canal system: Methodology: A questionnaire survey was conducted which was observational and descriptive, amongst 56 Endodontists over a period of 6 months. The questions were based on method of delivery of Intra-canal medicaments, as well as preference for these medicaments. Survey also asked the respondents about the importance of using ICMs in various endodontic conditions. Questions were also put forward that if they used different ICMs for different endodontic issues or prefer the same in all the cases. Results: While the vast majority of endodontist users in this scenario (87.5%) chose Non-setting Calcium Hydroxide, some of them (10%) used Formocresol. Others used triple antibiotic paste (2.5%). All endodontists (100%) used ICMs in cases of necrotic pulp with periapical lesions. Most respondents (48.8%) were in the habit of using injecting syringes to insert paste-based ICMs. Maximum using injecting syringes (48.8%), followed by Lentulo spirals (23.8%). Conclusion: Elimination of microbial contamination from the root canal system is a prerequisite to the successful outcome of root canal treatment and ICMs certainly help in this regard. However, all of the currently available antimicrobial materials for root canal irrigation and medication have limitations, and the search continues for the ideal irrigant and intra-appointment medicament.