Introduction: Congenitally missing maxillary lateral incisor is a most common anomaly that needs to be treated orthodontically in patients who does not prefer prosthesis. This case report will explain a novel approach to treat the agenesis of maxillary lateral incisor using skeletal anchorage system. Method: 20 years old female patients reported with a chief complaint of spacing and forwardly placed upper front teeth. On diagnosis, Angle`s class I dentoalveolar malocclusion on a class I skeletal base was evident with congenitally missing 12. Patient preferred for space closure of 12 regions. Bollard plate was surgically placed on left maxillary tuberosity. 2 TADs were inserted between 14, 15 & 22, 23. Initial alignment of teeth, levelling of bracket slots and space closure in 12 regions were achieved. Brass hooks were soldered on 0.021" X 0.025" SS arch wire at 2 spots - between 11, 21; 22, 23. E chain was given from bollard plates to hook between 22, 23. Also force was given from TAD placed on left quadrant to the hook soldered between 11, 21 and another between TAD of the right quadrant to the 2nd molar to achieve complete skewing of the arch and mesialisation of molar on right side to achieve class II molar relation. Result: Angle`s class II subdivision dentoalveolar malocclusion on a class I skeletal base was achieved with complete skewing of the dental arch to the left side using skeletal anchorage system.