Goal of prosthodontics is rehabilitation of missing oral and extra oral structures with restoration of normal function of mastication, speech, swallowing, esthetics etc. Defects of orofacial region, whether congenital or acquired, affects the patient physically and psychologically leading to poor quality of life. Benign and malignant lesions in the oral region are common, which requires surgical corrections. Surgical intervention of such lesions results in defects, affecting the function and esthetics of an individual. This case report explains prosthodontic rehabilitation of maxillectomy defect caused due to surgical excision of Ameloblastoma with Hollow bulb obturator with Cast partial denture. By fabrication of this prosthesis it covers the anatomic defect which forms communication among the oral cavity, nasal cavity and maxillary sinus.