Preeclampsia is a multifactorial disorder that is influenced by many factors that include genes, race and parity. The Renin angiotensin aldosterone system (RAAS) is vital in the regulation of blood pressure and has been implicated in the pathophysiology of preeclampsia among certain populations but such studies have been not reported in Nigeria. Angiotensinogen is the precursor molecule and a very important component of the RAAS. This pilot study investigated mutations in exon 2 of the angiotensinogen gene in preeclamptic women in Calabar, Nigeria. 19 preeclamptic and 20 normotensive pregnant women were recruited into the study from the University of Calabar Teaching Hospital, Calabar. Ethical approval and informed consent was obtained from the Ethics research committee and the women. Clinical variables were obtained and analyzed using a two tailed independent sample t-test, 3mls of blood was also collected from all the women. DNA was extracted, PCRs performed and the products were sequenced. Multiple sequence alignment was performed for all the sequenced products. This study observed a deletion of guanine at position 26 in all the 19 preeclamptic women and 5 tranversion mutations 4T>G, 911C>G, 1C>A, 795G>T, 912C>A in 17(89.5), 16(84.2), 4(21.1), 1(5.3) and 1(5.3) preeclamptic women respectively but not in the normotensive women. These results will serve as baseline information for subsequent molecular studies into the pathogenesis of preeclampsia among women in Calabar.