According to the studies, Saudi Arabia has acquired the 26th position in the Health care sector in the WHO ranking. Cancer is one of the leading health diseases in Saudi Arabia and other Arab countries. In Saudi Arabia, the Saudi Human Genome Project (SHGP) was initiated to understand the genetic distribution of Cancer cells. The aim of this study is to survey the opinion of people living in Saudi Arabia about Cancer. The opinion of the general adult population of Saudi Arabia about cancer is determined using a pre-designed, validated questionnaire. About 18.1 million cases of cancer were registered globally and 9.6 million death rates due to cancer were reported in the year 2018.The total mean score of this study was that 75% of the population residing in Saudi Arabia knows what Cancer is. To increase the knowledge of the people about signs and symptoms of Cancer and the cause of the Cancer and the preventions that can be taken at many cancer control activities need to be performed in Saudi Arabia. After carrying out the survey, we would like to increase other people's knowledge about Cancer and then motivate them to participate in cancer preventive activities.