The prime concept behind root canal treatment is to achieve a proper coronal and apical seal. Apicoectomy (root-end resection) with retrograde filling is a widely followed procedure to encounter the condition when all the efforts of endodontic treatment have failed. Among various ideal requirements of a root-end filling material, proper sealing ability is one of the most required properties. So, the selection of appropriate root-end filling material is to be done to prevent microleakage in the apical area after root-end resection. This study aims to evaluate the apical microleakage of two root-end filling materials. "Biodentine," which is known for its excellent biocompatibility and "MTA Repair HP," which has superior handling properties are compared in this study. Root canal treatment till obturation is done for all the samples. Root-end resection is done by removal of the apical 3mm with an angulation of 90° to the long axis of the tooth. The root end cavity of a depth 3mm is made. The samples were randomly divided into two groups, group 1 - MTA Repair HP, group 2 - Biodentine. Materials were manipulated according to the manufacturer’s instructions, and the root end cavities were filled with the respective materials of the belonging groups. Two coats of nail varnish is applied, and the samples were immersed in methylene blue dye. Dye penetration study was done, and specimens wereexamined under a stereomicroscope. Results are tabulated and statistically analyzed. Within the limitations of the study, it is concluded that, in comparison to these two root-ends filling materials, Biodentine showed the highest sealing ability and less microleakage compared to MTA Repair HP, which showed moderate microleakage.