Stem cells are biological cells that are undifferentiated and can be differentiate into specialized cells. They are of embryonic or adult stem cell. Another classification is dental pulp and bone marrow- derived. Bone marrow type stem cells are commonly used for regenerative procedures in prosthodontics. They have excellent regenerative ability without neoplasm formation. They help to build the bone structures of the craniofacial region, particularly the maxilla and mandible. Stem cell therapy can revolutionize next era in regenerative prosthodontics.