Fibrous dysplasia is a developmental anomaly which involves the replacement of normal medullary space by abnormal fibrous osseous tissue in the affected bone. It has been reported to cause increased rate of bone resorption and bone refilling has been observed in <50% of the defect. Patients with fibrous dysplasia can have periodontitis which is an immuno-inflammatory disease of the supporting tissues of the teeth with classic signs of periodontal pockets, recession or both. The goal of periodontal therapy is to thoroughly debride the periodontal pockets so as to prevent further damage to the surrounding bone and regenerate the lost periodontal structures. However, the treatment of periodontitis subjects with fibrous dysplasia is unpredictable and hence possesses a greater challenge for the clinician. This is a first report of its kind in the literature. This case report presents a 32year old patient with monostotic fibrous dysplasia having periodontitis and was treated by non surgical periodontal therapy which include scaling, root planning and curettage with soft tissue LASER as a non-invasive treatment modality. Laser assisted periodontal therapy resulted in resolution of the periodontal pocket as well as significant radiographic bone fill at the end of 6month recall visit.