Introduction: Mandibular third molar is commonly encountered impacted teeth. The present study aimed to assess relation of mandibular canal wit IANC. Materials & Methods: The present study was conducted on 82 patients with impacted mandibular third molar of both genders requiring surgical extraction. Patients underwent OPG and CBCT. Images thus obtained were analyzed by oral and maxillofacial radiologist followed by classification of Michele. Results: Out of 82 patients, males were 48 and females were 34. Darkening of roots (DR) was seen in 14 males and 10 females, diversion of canal (DC) in 10 males and 6 females, narrowing of canal (NC) in 8 males and 5 females, presence of cortication in 10 males and 7 females and interruption of white line (IWL) in 6 males and 6 females. The difference was significant (P< 0.05). Maximum number of subtype 3A relation was seen followed by subtype 1B, subtype 3A, subtype 3B, subtype 1A, subtype 4B etc. Conclusion: Authors found that impacted mandibular third molar surgery may lead to damage to inferior alveolar canal. Therefore a radiographic imaging with OPG and CBCT may be useful in preventing damage to the nerve.