Background: There were four antigens in ABO blood group system A,B,AB,O in human blood that significant for blood transfusion and hemolytic disease of new born. recent study also discover common ABO antigens relate with basal cell carcinoma, pancreatic cancer and other cancers disease , in this study we try to answer this question if polymorphism ABO blood group antigens can be cause of chronic kidney disease. Objectives: Detect the relationship between ABO blood group antigens and renal function test among chronic kidney disease patients in Khartoum state. Methods: Case control study blood samples of patient collected from dialysis centers and hospitals, the age from 6-72 years in Khartoum state were randomly selected for the study from May 2015 to June 2018, control group selected from central blood bank donated health people, blood samples were tested serological for ABO phenotype and renal function test. Result: Different ABO blood group in compared with renal function test show respectively A,B,AB and O in result of urea 131,149,116 and 121 mg/dl, creatinine 10.1,10.0,8.6 and 9.1 mg/dl, sodium 315,136,133and134mmol/l, potassium 4.5,4.6,3.9 and 4.5 mmol/l, finally uric acid 7.2,6.1,5.9 and 6.8mg/dl. Conclusions: No significant relation of ABO antigens as cause of chronic renal disease.