Aim: The aim of this study is to compare the Solubility of Endosequence root repair material fast set putty and Mineral Trioxide Aggregate Angelus (MTA-Angelus). Methods and Material: Solubility was determined by preparing stainless steel ring molds which were filled with cements corresponding to two groups (n = 5). Samples were transferred to bottles containing 10 ml of distilled water and stored at 37°C for 1, 7, and 21 days. Solubility was measured as the difference between the initial weight and the weight at the end of each storage period. Results were analyzed using Mann Whitney U test and Wilcoxon signed rank sum test. Results: The results showed weight loss with time for both materials. The solubility of ERRM and MTA on 21 days was more compared to its solubility after 1 and 7 days. Conclusions: There was no significant difference in solubility between endosequence root repair material and mineral trioxide aggregate.