The demand of aesthetic orthodontics has increased among young and adult population. The request for fast and invisible orthodontic treatment has encouraged the development of clear aligners. Clear aligners are considered as an alternative to dental braces. They are devices that use thermoplastic materials which apply pressure to teeth to move into the desired position. Dozens of company around world offer some type of clear aligner orthodontic product and is widely considered as the future of Orthodontics. Advantages of sequential aligner therapy has been discussed widely, this article discuss concerns and adverse effects and reactions associated with aligner therapy. However, until more clinical research becomes available, aligners cannot be routinely prescribed as an effective alternative to fixed labial appliances. Let us look before we leap.