Background: Unicystic ameloblastoma is one of the different clinical variants of ameloblastoma which is less aggressive in its biological behavior. Aim: The present study was undertaken to retrospectively compare the clinical, radiologic, and histopathologic features of 50 cases of unicystic ameloblastoma in Indians. Methods: Biopsy records of 50 histologically diagnosed cases of unicystic ameloblastoma over 9-year (2010-2019) period were retrieved and analyzed for age, sex, site distribution, clinical presentation, radiologic features, and histopathology. Results: It was revealed that out of 50 cases, a male preponderance was seen. Age predisposition was seen to favor the 2nd to 3rd decade, the most common site was the posterior aspect of lower jaw. Common histological type noted was luminal and intramural type (1.3). Conclusion: The study provides baseline data regarding the viable record for the distribution of odontogenic lesions in the sample population.