Background: To ascertain if fluoridated dentifrices have an effect on Streptococcus mutans count in orthodontic patients with Polycarbonate brackets. Material and method: patient had tooth No’s 45 included in the study with Polycarbonate bracket bonded. Dentifrices tested were Fluoride based. Conventional tooth paste was considered as control group. Result: Paired T test compared the means of Streptococcus mutans count around Polycarbonate bracket at different time intervals. Conclusion: This shows Polycarbonate bracket has statistically significant reduction of Streptococcus mutans with Fluoride toothpaste.