Background: The extraction of the mandibular third molars is one of the most commonly performed dentoalveolar procedures in oral and maxillofacial surgery and it is often associated with varying degree of postoperative discomfort. Pain, swelling and trismus are the most common postoperative complaints. These discomforts greatly influence the quality of life of the patients in the days after the dental procedure. Objective: The study was conducted to evaluate the efficiency of various analgesics namely paracetamol, ketorolac, ibuprofen, tramadol and diclofenac in one, three and five days of the postoperative administration of the analgesics. Methodology: In the present study, twenty five systemically healthy male subjects were included who were undergoing non-surgical extraction of mandibular third molar due to grossly decayed tooth. The subjects were divided into five groups with five subjects in each group according to the analgesic they had received postoperatively; namely paracetamol, ketorolac, ibuprofen, tramadol and diclofenac. Pain was assessed by using a Visual Analog Scale (VAS) respectively on one, three and five days of administration of analgesics postoperatively. A data was collected on the respective days. The recorded data was tabulated and analyzed accordingly. As the data for this study were collected at different time points, analysis for the longitudinal study was done. Result: The outcome of the present study revealed that the efficiency of all the analgesics was almost similar with a sound management of acute postoperative pain. According to results, ketorolac has shown a relatively better effect on the pain control after one day of administration of the drug. After three days of administration of the drugs, the efficacy of all the analgesics except that of paracetamol was almost similar and the efficiency of all the analgesics was equal after the five days as all them could control the pain successfully and there was no pain experienced by any the patients after five days of the dental procedure. Moreover, the non- NSAID i.e., tramadol also had shown similar efficiency as that of NSAIDs. Thereby, in the present study, the analgesics have shown almost equal efficacy at different time points. Conclusion: This study has demonstrated that there was no significant difference in the efficiency of all the analgesics included in the present study and they were able to alleviate the postoperative pain evaluated at different point of time.